4 edition of Peptide Transport and Delivery into the Central Nervous System (Progress in Drug Research) found in the catalog.
November 13, 2003
by Birkhäuser Basel
Written in English
|Contributions||Laszlo Prokai (Editor), Katalin Prokai-Tatrai (Editor)|
|The Physical Object|
|Number of Pages||248|
Peptides such as g7 (NH2-Gly-L-Phe-D-Thr-Gly-L-Phe-L-Leu-L-Ser(O-β-D-Glucose)-COOH, g7) are similar to opioid peptides and can be employed to deliver model drugs into the central nervous system. G7 bound to PLGA NPs also enabled the delivery of loperamide and yielded prolonged antinociceptive reactions. The reason for this behaviour is not clear; since it is known that the parent opioid peptides . Peptides have long been recognized as a promising group of therapeutic substances to treat various diseases. Delivery systems for peptides have been under development since the discovery of insulin for the treatment of diabetes. The challenge of using peptides as drugs arises from their poor bioavailability resulting from the low permeability of biological membranes and their instability.
Purchase Nanomedicine, Volume - 1st Edition. Print Book & E-Book. ISBN , The intricate microstructure of the blood-brain barrier (BBB) is responsible for the accurate intrinsic regulation of the central nervous system (CNS), in terms of neuronal pathophysiological phenomena. Any disruption to the BBB can be associated with genetic defects triggering or with local antigenic invasion (either neurotoxic blood-derived metabolites and residues or microbial pathogens).
The hypothesis that the impaired ability of the blood–brain barrier (BBB) to remove amyloid-β peptide from the central nervous system (CNS) . Anatomy and physiology of Central Nervous System 1. Dr Himanshu Jangid Anatomy and Physiology of CNS 2. The Brain: embryonic development Develops from neural tube Brain subdivides into Forebrain Midbrain Hindbrain These further divide, each with a fluid filled region: ventricle, aqueduct or canal Spinal cord also has a canal Two major bends, or flexures, occur .
Leading the retail revolution
Vault guide to the top 50 management and strategy consulting firms
Lifes interruptions, Gods opportunities
biological fate of vinylidene chloride in mammals.
The later adventuresof Tom Jones.
Richard Lester and the Beatles
Natural language analysis to support biomimetic design.
Partners in crime
Time and the Conways
The Raymond Chandler omnibus.
Planning in Jersey
Peptide Transport and Delivery Into the Central Nervous System (Progress in Drug Research): Medicine & Health Science Books @ mat: Paperback. Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS).
Various peptides native to the brain and the spinal cord, as well as various. Peptide Transport and Delivery into the Central Nervous System. Editors (view affiliations) and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS).
which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery. Peptide Transport and Delivery into the Central Nervous System Author: Prof. Laszlo Prokai, Prof. Katalin Prokai-Tatrai Published by Birkhäuser Basel ISBN: DOI: / Table of Contents: Neuropeptides: general characteristics and neuropharmaceutical potential in treating CNS disorders.
Peptide and Amino Acid Transport Mechanisms in the Central Nervous System [Rakic, L.] on *FREE* shipping on qualifying offers. Peptide and Amino Acid Transport Mechanisms in the Central Nervous SystemCited by: Peptide Transport and Delivery into the Central Nervous System Article Literature Review in Fortschritte der Arzneimittelforschung.
Progress in drug research. Delivery into the Central Nervous System Vol. 61 Edited by Laszlo Prokai and Katalin Prokai-Tatrai Peptide transport across the blood-brain barrier 79 CNS-delivery via conjugation to biological carriers: physiological-based approaches Transport and Delivery into the Central Nervous System”consists of eight reviews by internationally known experts covering the most important aspects pertaining to the emerging field of peptide.
Delivery of peptides into the central nervous Laszlo Prokai Research into the delivery of potentially useful peptide therapeutic agents to the CNS has lagged behind the Cited by: 6.
Peptide Transport and Delivery into the Central Nervous System de - English books - commander la livre de la catégorie Médecine sans frais de port et bon marché - Ex Libris boutique en ligne.
Potential applications of polymers in the delivery of drugs to the central nervous system. Colloids and Surfaces B: Biointerfaces16 (), DOI: /S(99)X. Eain M. Cornford, Shigeyo Hyman. Blood–brain barrier permeability to small and large molecules.
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics.
Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics could be useful in the treatment of diseases of the central nervous system.
This book provides an overview of the role and neuropharmaceutical potential of these peptides. Many central nervous system (CNS) diseases and disorders remain very difficult to treat because of the limiting effect of blood-brain barrier (BBB) on delivery of drugs into the CNS. A limited Modifying peptide properties by prodrug design for enhanced transport into the CNS | SpringerLinkCited by: Get this from a library.
Peptide Transport and Delivery into the Central Nervous System. [Laszlo Prokai; Katalin Prokai-Tatrai] -- Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous.
CMT systems transport nutrients, vitamins or hormones into the central nervous system. This type of transport was firstly investigated in vivo with physiologic techniques [ 53, 54 ] allowing determination of the Michaelis-Menten kinetic parameters (K m, expressing the substrate-transporter affinity and V max, expressing the transporter.
Most peptides do not enter the central nervous system because of their hydrophilic character and the presence of peptidolytic enzymes in the lipoidal blood-brain barrier. To achieve brain delivery of a peptide conjugate, an opioid peptide (enkephalin) was placed in a molecular environment that disguises its peptide nature and provides biolabile, lipophilic functions to penetrate the blood.
JCR Topic Collection: Central Nervous System Drug Delivery Volume 2, Issue 2 The papers listed in this issue of JCR Topic Collections were previously published in Journal of Controlled Release in Volumes Editors: Chenlu Lei and Chi-Hwa Wang. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans.
In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. Although RVG peptide can bind to neuronal cells, it does not bind nucleic acids and therefore cannot be used to transport siRNA.
However, short, positively charged, cell Cited by:. Bodor, N. and Prokai, L., Molecular packaging: peptide delivery to the central nervous system by sequential metabolism, in Taylor M: Amidon G (eds), Peptide-Based Drug Design: Controlling Transport and Metabolism.
American Chemical Society, Washington, DC, pp –, Peptide-based vectors for blood–brain barrier targeting and delivery of drugs to the central nervous system. Patrick Vlieghe; and are currently being developed by biotechnology companies to enhance the transport of drugs from blood into the CNS.
use of implants or convection-enhanced delivery), into the brain.Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood–brain barrier drug delivery system.
J. Pharmacol. Exp. Ther. ,77–83 ().Medline, CAS, Google Scholar; 33 Wu D, Pardridge WM. Neuroprotection with noninvasive neurotrophin.